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| Name | Mouse anti Interleukin 1alpha (IL-1alpha) |
|---|---|
| Catalog number | L124M |
| Size | 500 μg |
| Price | € 345.00 |
| Category | Primary Antibodies |
|---|---|
| Long description | Interleukin 1 Receptor Antagonist inhibits the activity of IL-1 by binding to its receptor and has no IL-1 like activity._x000B__x000B_Genetic variation in IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis._x000B__x000B_Defects in IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA), also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis (bone inflammation in multiple places), periostitis (inflammation of the membrane surrounding the bones), and pustulosis (due to skin inflammation) from birth. |
| Antibody come from | n/a |
| Other description | Provided as sterile filtered solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein. Protein A/G Chromatography |
| Clone | AS8 |
| Antigen-antibody binding interaction | Mouse anti Interleukin 1alpha (IL-1alpha) Antibody |
| Antibody is raised in | Mouse |
| Antibody's reacts with | Human |
| Antibody's reacts with these species | This antibody doesn't cross react with other species |
| Antibody's specificity | No Data Available |
| Application | ELISA |
| Antibody's suited for | Optimal concentration should be evaluated by serial dilutions. This antibody has been used at 10 µl per test (10^5-10^6 cells) to stain intracellular human IL-1RA expressed in Brefeldin A-treated monocytes and macrophages. |
| Storage | -20ºC |
| Relevant references | no information yet |
| Protein number | see ncbi |
| Warnings | This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information. |
| Description | This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. |
| Test | Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain. |
| Latin name | Mus musculus |