Mouse anti NGF (Nerve Growth Factor)

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Main information

NameMouse anti NGF (Nerve Growth Factor)
Catalog numberL146M
Size500 μg
Price€ 345.00


More details

CategoryPrimary Antibodies
Long descriptionNerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. Recently, it has been shown that cells which do not normally respond to NGF only express low affinity receptors from transfected NGF genes but cells which normally are NGF-responsive express high affinity receptors from the same NGF sequences. This supports the hypothesis that the high affinity receptors have a unique component in addition to the subunit common to the low affinity receptors.
Antibody come fromHybridoma produced by the fusion of splenocytes from BALB/c mice immunized with human recombinant nerve growth factor and mouse myeloma cells.
Other descriptionProvided as solution in phosphate buffered saline, no preservative. Protein A/G Chromatography
CloneAS18
Antigen-antibody binding interactionMouse anti NGF (Nerve Growth Factor) Antibody
Antibody is raised inMouse
Antibody's reacts withHuman, Mouse, Bovine, Viper
Antibody's reacts with these speciesThis antibody doesn't cross react with other species
Antibody's specificityNo Data Available
ApplicationNeutralization, Enzyme Immunoassay, IP
Antibody's suited forAntibody can be used for immunoprecipitation. Optimal concentration should be evaluated by serial dilutions. Applications: EIA, Neutralizing
Storage-80ºC
Relevant references1. Kitamura, T., et al., J. Cell Physiol. 1989: 140, 322._x000B__x000B_2. Francke, U., et al., Science 1983: 222, 1248._x000B__x000B_3. Zabel, B., et al., Proc. Natl. Acad. Sci. USA 1985: 82, 469._x000B__x000B_4. Selby, M. et al., Mol. Cell Biol. 1987: 7, 3057.
Protein numbersee ncbi
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Tissuenerve
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin nameMus musculus