Mouse anti Cytokeratin 2e

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Main information

NameMouse anti Cytokeratin 2e
Catalog numberMUB0342S
Size1 mL
Price€ 211.00

More details

CategoryPrimary Antibodies
Long descriptionCytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in Human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 – 7.8. The individual Human Cytokeratins are numbered 1 to 20. The various epithelia in the Human body usually express Cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of matuRation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The Cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Antibody come fromKs2.342.7.1 is a Mouse monoclonal IgG1 antibody derived by fusion of Mouse myeloma cells with spleen cells from a Balb/c Mouse immunized with a cytoskeletal preparation.
Other descriptionEach vial contains 1 ml of culture supernatant of monclonal antibody containing 0.09% sodium azide.
Antigen-antibody binding interactionMouse anti Cytokeratin 2e Antibody
Antibody is raised inMouse
Antibody's reacts withBovine,Human,Mouse,Rat
Antibody's reacts with these speciesThis antibody doesn't cross react with other species
Antibody's specificityBasic Human Keratin K2, also designated Cytokeratin 2e; reactive with epidermal cells in uppermost suprabasal layers; recognizes individual cells within epidermis of tongue and mamille (co-localization with Keratin K10); also reactive on hyperkeRatosis of diverse viral and genetic origin.
Research interestCytoskeleton
ApplicationImmunohistochemistry (frozen),Immunohistochemistry (paraffin),Immunoprecipitation,Western blotting
Antibody's suited forKs2.342.7.1 is suitable for immunoprecipitation, immunoblotting and immunohistochemistry on frozen and paraffin-embedded tissues. Optimal antibody dilution should be determined by titration.
StorageStore at 4°C, or in small aliquots at –20°C.
Relevant referencesCollin C., Moll R., Kubicka S., Ouhayoun J.-P. and Franke W.W. (1992). Characterization of Human Cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation, Exp. Cell Res. 202: 132-141.2. Swensson O, Langbein L, McMillan JR, Churchill LJ, Leigh IM, McLean WHI, Lane EB, Eady RAJ. Specialized Keratin expression pattern in Human ridged skin as an adaption to high physical stress. Br.J.Dermatol. 139, 767-775 (1998).
Protein numberP35908
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin nameMus musculus