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| Name | Mouse anti Fibronectin |
|---|---|
| Catalog number | MUB0602S |
| Size | 1 mL |
| Price | € 211.00 |
| Category | Primary Antibodies |
|---|---|
| Long description | Fibronectin is a disulfide-bonded dimer of 230-250 kD. In the extracellular matrix of several connective tissues and vessels, fibronectin is present as an insoluble protein that is extensively cross-linked by interchain disulfide bonds forming high molecular mass polymers. It is most abundant during embryonic development and tissue remodelling. Fibronectin is also present at high concentRations as a soluble plasma protein. Fibronectin is organized as a linear series of repeating modules which form domains for interaction with fibronectin itself, other matrix components (e.g. collagen and heparin) and receptors on cells (e.g. integrins). |
| Antibody come from | EP-5 is a Mouse monoclonal IgG1 antibody. |
| Other description | Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide. |
| Clone | EP-5 |
| Antigen-antibody binding interaction | Mouse anti Fibronectin Antibody |
| Antibody is raised in | Mouse |
| Antibody's reacts with | Human,Mouse |
| Antibody's reacts with these species | This antibody doesn't cross react with other species |
| Antibody's specificity | EP-5 reacts with fibronectin in connective tissues and vessels. Animal biodistribution experiments have shown that after intravenous administRation, EP-5 antibody localizes to tumor vessels where it binds to the underlying basement membrane. At the same time the antigen recognized by EP-5 antibody is not accessible in normal tissue to circulating antibody indiCating that this antibody can be used to target tumor vessels specifically in vivo. |
| Research interest | Cell adhesion |
| Application | Immunohistochemistry (frozen) |
| Antibody's suited for | EP-5 is useful for immunohistochemistry on frozen tissues. Optimal antibody dilution should be determined by titration; recommended range is 1:2 – 1:10 for immunohistochemistry with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent. |
| Storage | Store at 4°C, or in small aliquots at -20°C. |
| Relevant references | 1. No references available |
| Protein number | P02751 |
| Warnings | This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information. |
| Description | This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. |
| Test | Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain. |
| Latin name | Mus musculus |