| Category | Primary Antibodies |
|---|
| Long description | Lung cancer is a heterogeneous disease, which can be subdivided into five major tyoes based on histopathological criteria like squamous cell carcinomas, adenocarcinoma, large cell carcinoma, adenosquamous carcinoma and small cell lung cancer (SCLC). A number of important prognostic characteristics have been identified to include the extend of disease and especially for SCLC, tumor sensitivity to chemotherapy. The monoclonal antibody MOC-1 is reactive with lung cancer associated antigens and stains neural and a variable number of endocrine tissues. In the lung it reacts preferentially with SCLC and carcinoids. MOC-1 was defined as a cluster I antibody during the First International Workshop on Small Cell Lung Cancer (SCLC) Antibodies. MOC-1 recognizes NCAM which is present in small cell lung cancer (SCLC) and lung carcinoids. |
|---|
| Antibody come from | MOC-1 is a Mouse monoclonal IgG1 antibody and is coming from a small cell lung carcinoma derived cell line preparation. Hybridoma's: Mouse myeloma X 63-BALB/c. |
|---|
| Other description | Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide. |
|---|
| Clone | MOC-1 |
|---|
| Antigen-antibody binding interaction | Mouse anti MOC-1 / CD56 Antibody |
|---|
| Antibody is raised in | Mouse |
|---|
| Antibody's reacts with | Human,Mouse |
|---|
| Antibody's reacts with these species | This antibody doesn't cross react with other species |
|---|
| Antibody's specificity | MOC-1 is reactive with almost all SCLC cases and has a molecular weight of about 145 kD. |
|---|
| Research interest | Cancer,Cell adhesion, CD Markers |
|---|
| Application | Flow Cytometry,Immunocytochemistry,Immunohistochemistry (frozen),Western blotting |
|---|
| Antibody's suited for | MOC-1 is suitable for immunocytochemistry and immunohistochemistry on frozen tissues, for flow cytometry and for staining with avidin-biotinylated Horseradish peroxidase complex (ABC) as detection reagent Optimal antibody for immuno histochemistry is 1:2 – 1:10. |
|---|
| Storage | Store at 4°C, or in small aliquots at -20°C. |
|---|
| Relevant references | World Health Organization (1982). The WHO histological typing of tumors. 2nd ed. Am. Journal Clinical Pathology 77, 123-36. Bedendsen, HH. (1988). Search for the therapy resistant phenotype in lung cancer. Thesis Groningen. Souhami, R.L. et al. (1987). Antigens of small cell lung cancer. Lancet ii 325-26. De Leij, et al. (1987). Monoclonal antibodies in clinical and experimental pathology of lung cancer. AppliCation of monoclonal antibodies in tumor pathology (Ruiter, D.J. et al. Eds). Dordrecht; Martinus Nijhoff 191-210. |
|---|
| Protein number | see ncbi |
|---|
| Warnings | This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information. |
|---|
| Description | This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. |
|---|
| Test | Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain. |
|---|
| Latin name | Mus musculus |
|---|