| Category | Primary Antibodies |
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| Long description | Tiam1, also known as T-cell lymphoma invasion and metastasis-inducing protein 1, is a protein that in Humans is encoded by the TIAM1 gene. TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain. TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA. TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas. |
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| Antibody come from | F5S F6.2 is a Mouse monoclonal IgG2b antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with T-cell lymphoma invasion and metastasis-inducing protein 1 (Tiam1). |
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| Other description | Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide. |
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| Clone | F5S F6.2 |
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| Antigen-antibody binding interaction | Mouse anti TIAM Antibody |
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| Antibody is raised in | Mouse |
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| Antibody's reacts with | Human |
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| Antibody's reacts with these species | This antibody doesn't cross react with other species |
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| Antibody's specificity | F5S F6.2 is a Mouse monoclonal directed anti the N-terminal region of Tiam1. |
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| Research interest | Cancer,Immunology,Neurobiology |
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| Application | Immunohistochemistry (frozen),Western blotting |
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| Antibody's suited for | F5S F6.2 is useful for western blot and immunohistochemistry on frozen sections. Optimal antibody dilution should be determined by titration. |
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| Storage | Store at 4°C, or in small aliquots at -20°C. |
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| Relevant references | 1. No references available |
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| Protein number | see ncbi |
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| Warnings | This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information. |
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| Description | This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. |
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| Test | Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain. |
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| Latin name | Mus musculus |
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