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| Name | Mouse anti Rb (Retinoblastoma) |
|---|---|
| Catalog number | N120M |
| Size | 100 μg |
| Price | € 304.00 |
| Category | Primary Antibodies |
|---|---|
| Long description | The immunogen for the anti-human retinoblastoma (Rb) was a recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence. Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes. |
| Antibody come from | A recombinant protein corresponding to amino acids 393 to 572 of the human retinoblastoma sequence |
| Other description | Provided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography |
| Clone | XZ104 |
| Antigen-antibody binding interaction | Mouse anti Rb (Retinoblastoma) Antibody |
| Antibody is raised in | Mouse |
| Antibody's reacts with | Human |
| Antibody's reacts with these species | This antibody doesn't cross react with other species |
| Antibody's specificity | No Data Available |
| Application | Immunoprecipitation |
| Antibody's suited for | Applications: Immunoprecipitation (not recommended for Western blotting or immunohistochemistry). |
| Storage | -20ºC |
| Relevant references | 1) Hu, Q.J., et. al. 'Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.' Mol. Cell Biol. 1991, 11: 5792-5799 _x000B__x000B_2) Harlow, E., 'Retinoblastoma. For our eyes only.' Nature 1992, 359, 270-271 _x000B__x000B_3) Dyson, N., et al. 'Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.' J. Virol. 1992, 4606-4611 _x000B__x000B_4) Zarkowska, T., et al., 'Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs.' Oncogene 1997, 14, 249-254 _x000B__x000B_5) Lai, A., et al. 'RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth Arrest. |
| Protein number | see ncbi |
| Warnings | This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information. |
| Description | This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. |
| Test | Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain. |
| Latin name | Mus musculus |