Mouse anti Estrogen Receptor

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Main information

NameMouse anti Estrogen Receptor
Catalog numberX1266M
Size100 μg
Price€ 304.00


More details

CategoryPrimary Antibodies
Long descriptionThe human estrogen receptor has a molecular weight of 67 kDa and consists of 6 functional domains (domains A-F). Functional mapping of the estrogen receptor has determined a transcriptional promoting activity in the A/B domain. The hormone-binding domain (E domain) is located towards the carboxy terminal, whereas the DNA-binding domain (C domain) is found in the central portion of the molecule. It has been speculated that the presence in breast cancer cells of truncated forms of the estrogen receptor lacking the hormone-binding domain might promote the uncontrolled growth of the tumor.
Antibody come fromn/a
Other descriptionProtein A/G Chromatography
CloneAER311
Antigen-antibody binding interactionMouse anti Estrogen Receptor Antibody
Antibody is raised inMouse
Antibody's reacts withHuman, Mouse
Antibody's reacts with these speciesThis antibody doesn't cross react with other species
Antibody's specificityNo Data Available
ApplicationWestern Blot, Immunoprecipitation, Immunohistochemistry,Enzyme Immunoassay_x000B_
Antibody's suited forThe Exalpha Biologicals, Inc. PIG3 ELISA is a non-isotopic immunoassay for the 'in vitroÓ quantitation of human PIG3 protein in cell lysates, tissue culture medium, sera and plasma.
Storage-20ºC
Relevant references1. p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. Flatt, P.M., et al., 'Cancer Lett.' 2000, 156, 63-73._x000B__x000B_2. The requirement for the p53 proline-rich functional domain for the mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression. Venot, C., et al., 'EMBO J.' 1998, 17, 4668-4679._x000B__x000B_3. Regulation of p53 downstream genes. el-Deiry, W.S., Semin. 'Cancer Biol.' 1998, 8, 345-357._x000B__x000B_4. Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1 Gad Asher, Joseph Lotem, Batya Cohen, Leo Sachs, and Yosef Shaul. 1188-1193, 'PNAS,' Janualry 30, 2001. vol. 98, no. 3._x000B__x000B_5. Characterization of distinct consecutive phases in non-genotoxic p53-induced apoptosis of Ewing tumor cells and the rate-limiting role of caspase 8. Kovar H, Jug G, Printz D, Bartl S, Schmid G, Wesierska-Gadek J. 'Oncogene' 2000 Aug 29:4096-107._x000B__x000B_7. The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression. Corinne Venot, Michel Maratrat, Christine Dureuil, Emmanuel Conseiller, Laurent Bracco, and Laurent Debussche. 'EMBO Journal' Vol. 17 No.16 pp.4668-4679, 1998.
Protein numbersee ncbi
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin nameMus musculus