Mouse anti Mismatch Repair Protein 2 (MSH2)

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Main information

NameMouse anti Mismatch Repair Protein 2 (MSH2)
Catalog numberX1406M
Size500uL
Price€ 500.00


More details

CategoryPrimary Antibodies
Long descriptionRecognizes a ~102kDa identified as MSH2. Germline mutations in human mismatch repair genes (hMSH2, hMSH6, hMLH1, hPMS2) account for majority of the hereditary non-polyposis colorectal carcinoma (HPNCC). CpG dinucleotides in the hMSH2 and hMLH1 genes are hotspots for HNPCC mutations. These mutations cause a mismatch repair deficiency resulting in a mutator phenotype where the replication errors are not repaired. Microsatellites / simple repeatative sequences are prone to this type of replication errors and instability of these microsatellites correlates with the occurance of HPNCC. hMSH2 binds to another MutS homolog protein GTBP to form a heterodimeric complex called hMutSbeta, which binds to insertion/deletion loops in DNA.
Antibody come fromRecombinant protein derived from the extracellular domain of the chicken TGF III receptor protein. Protein shares significant homology with the mouse, rat and human sequences.
Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide.
Clone2MSH01
Antigen-antibody binding interactionMouse anti Mismatch Repair Protein 2 (MSH2) Antibody
Antibody is raised inMouse
Antibody's reacts withHuman
Antibody's reacts with these speciesThis antibody doesn't cross react with other species
Antibody's specificityNo Data Available
ApplicationImmunohistochemistry (Frozen & Paraffin Sections)
Antibody's suited forAntibody can be used for Western blotting (5-10 µg/ml), immunoprecipitation (5 µg/mg of protein lysate and immunohistochemistry on paraffin embedded tissue sections (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Storage-20ºC
Relevant references1. Brown, C.B., et al. 'Requirement of type III TGF- receptor for endocardial cell transformation in the heart.' Science 1999, 283, 2080-2082
Protein numbersee ncbi
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin nameMus musculus