Mouse anti von Hippel-Lindau Protein

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Main information

NameMouse anti von Hippel-Lindau Protein
Catalog numberX1479M
Size100 μg
Price€ 500.00


More details

CategoryPrimary Antibodies
Long descriptionIt recognizes a protein of 30kDa which is specifically identified as von Hippel-Lindau protein (VHL). Epitope of this antibody localizes between amino acids 1-54 as it does not recognize the truncated form of VHL protein. Alterations in the von Hippel-Lindau (VHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC), and pheochromocytoma. Molecular genetic studies suggest that VHL is a tumor-suppressor gene; correspondingly, reintroduction of a VHL complementary DNA (cDNA) into RCC cells inhibits their ability to form tumors in nude mice. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation.
Antibody come fromSynthetic peptide derived from the rat Kv1.2 potassium channel conjugated to KLH
Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
CloneIg33
Antigen-antibody binding interactionMouse anti von Hippel-Lindau Protein Antibody
Antibody is raised inMouse
Antibody's reacts withHuman
Antibody's reacts with these speciesThis antibody doesn't cross react with other species
Antibody's specificityNo Data Available
ApplicationWestern Blot, Immunoprecipitation, Immunohistochemistry
Antibody's suited forThis antibody can be used for Western blotting (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Storage-20ºC
Relevant references1. McKinnon,D 'Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family' J. Biol. Chem. 264 (14), 8230-8236 (1989)_x000B__x000B_2. Stuhmer,W et.al 'Molecular basis of functional diversity of voltage-gated potassium_x000B_channels in mammalian brain' EMBO J. 8 (11), 3235-3244 (1989)_x000B__x000B_3. Roberds,S.L et.al 'Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart' Proc. Natl. Acad. Sci. U.S.A. 88 (5), 1798-1802 (1991) _x000B__x000B_4. Confuti,L. et al. 'O2-sensitive K+ channels: role of the Kv1.2 -subunit in mediating the hypoxic response.' J Physiol 524 Pt 3:783-93. (2000)_x000B__x000B_5. Nashimi,R.et.al 'Abnormal axonal physiology is associated with altered expression and distribution of Kv1.1 and Kv1.2 K+ channels after chronic spinal cord injury.' Eur J Neurosci.12(2):491-506 (2000)_x000B_
Protein numbersee ncbi
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin nameMus musculus