Mouse anti p53 (a.a. 371-380)

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Main information

NameMouse anti p53 (a.a. 371-380)
Catalog numberX1494M
Size100 μg
Price€ 304.00


More details

CategoryPrimary Antibodies
Long descriptionp53 is a 53 kDa transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others.
Antibody come fromSynthetic peptide derived from the rat alpha1E calcium channel conjugated to KLH
Other descriptionProvided as solution in phosphate buffered saline with 0.08% sodium azide. Protein A/G Chromatography
ClonePab122
Antigen-antibody binding interactionMouse anti p53 (a.a. 371-380) Antibody
Antibody is raised inMouse
Antibody's reacts withHuman, Mouse, Rat, Monkey, Hamster
Antibody's reacts with these speciesThis antibody doesn't cross react with other species
Antibody's specificityNo Data Available
ApplicationImmunoprecipitation, Flow Cytometry, Immunofluorescense
Antibody's suited forThis antibody can be used for Western blotting (5-10 µg/ml). Optimal concentration should be evaluated by serial dilutions.
Storage-20ºC
Relevant references1. Soong,T.W et al. 'Structure and functional expression of a member of the low voltage-activated calcium channel family' Science 260 (5111), 1133-1136 (1993)_x000B__x000B_2. Chen, S. et al. 'Alpha 1E subunit of the R-type calcium channel is associated with myelinogenesis.' J. Neurocytol. 29(10), 719-28 (2000)
Protein numbersee ncbi
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin nameMus musculus