anti-Akt1 Antibody

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Main information

Nameanti-Akt1 Antibody
Catalog number3519
Size0.02 mg, 0.1 mg
Price€ 180.00


More details

Gene infoAkt1 Antibody: Akt1, initially identified as the cellular homolog to the retro-viral oncogene v-Akt, is part of the phosphatidyl 3'-kinase (PI3K)-Akt signaling pathway that is activated by diverse cellular stimuli and regulates critical cellular functions such as cell growth, proliferation, and survival. Following phosphorylation of the second messenger PIP2 by PI3K, Akt1 translocates to the cell membrane where it is activated by phosphoinositide-dependent kinase (PDK) 1 and PDK2. The active Akt1 is then able to phosphorylate and activate its substrates, including those that are important for cell proliferation and survival such as TOR and the Bcl-2 homolog Bad. Negative regulation of the PI3K-Akt signaling pathway is mainly accomplished by the lipid phosphatase activity of PTEN which catalyzes the conversion of PIP3 to PIP2, thereby preventing the activation of Akt1. Inactivation of this gene often results in excessive Akt1 activity, often leading to the formation of malignant tumors.
Gene namesAkt1 Antibody: AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA, Protein kinase B
Antibodie's labelunlabelled serum
PurityAkt1 Antibody is affinity chromatography purified via peptide column.
Ab raised inRabbit
TypePolyclonal
ImmunoglobulinIgG
AntigenAkt1 antibody was made against a 16 amino acid synthetic peptide from near the amino-terminus of human Akt1.
Immuno applicationELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence, immuno precipitation
Antibody adviceAkt1 antibody can be used for the detection of Akt1 by Western blot at 1 to 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2 ug/mL. For immunofluorescence start at 20 ug/mL.
Suspention, pH, azideAkt1 Antibody is supplied in PBS containing 0.02% sodium azide.
Keep atAkt1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Works withHuman, Mouse, Rat
Omim nr12653417
Ncbi nrAAH00479
Vial with antibodyin solution
Quantity per ml1 mg/mL
NCBI GENE nr207
GENE symbolAKT1
Antigene namev-akt murine thymoma viral oncogene homolog 1
SourceHomo sapiens
Protein nrP31749
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translationanticorps